در هنگام جستجو کلمه در قسمت عنوان میتوانید کلمات مورد جستجو را با کاراکتر (-) جدا کنید.
کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Journal of Kerman University of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Histopathology,Biomechanics,supe nylon,ethicon nylon,rat skin
- چکیده:
- چکیده انگلیسی: This study was designed to elucidate the possible difference between supa and ethicon.nylon in suturing rat skin.75 female spragne-dawley albino rats with mean weight 250 g were used and randomly divided into three groups of 30,30 and 15 rats.in 60 rats anesthesea was induced by ketamin and xylazin.followed by surgical preparation , a 5 cm abdominal skin incision was made and sutured by simple interrupted suture pattern.in group n1,3/0 nylon,supa product and in group 2,3/0 nylon ethicon product were used.15 animals of each group were sacrificed on day 6th for Histopathologic examination and the rest of the animals on day 13th for Histopathologic and biomechanical examination .15 rats were sarsified for biomechanical evaluation of normal skin.Histopathologic sections were stained by H&E and examined under light microscope for reepithelization,acanthosis,age of granulation tissue ,type of predominant inflammatory cells,hyperemia and the presence of giant cells.tissue repair in group 2 was significantly more mature than group 1 on day 6 th (p<_0.05).threr was no significant difference between the two groups on day 13th.in biomechanical study.the following parameters were measured form load-elongation curve:linear starting point,yield point,ultimate streagth,stiffness,ultimate strain,maximum stored energy and yield stored energy.the steffness of group 1 samples was significantly more than group 2 (p<_0.05).there were no significant differnces between the two groups in other biomechanical parameters.according to the results of this study it can be concluded that concerning short term tissue reactions.ethicon nylon suture is superior to supa,though threr was no significant histopathologic difference between the two groups on day 13.however ,cystic structures were observed onlt in group 2.the biomechanical quality of group 2 was also superior to group 1.
- انتشار مقاله: 18-07-1395
- نویسندگان: M.M Olomi,A Derakhshanfar,A.A Kalantari
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Iron and Steel Society of Iran
- نوع مقاله: Journal Article
- کلمات کلیدی: density,Mechanical properties,Low alloyed sintered steel,sintering temperature,electrical-conductivity
- چکیده:
- چکیده انگلیسی: Producing parts with high density and improved mechanical properties is one of the most important aims of powder metallurgy process. There are many factors for attaining modified properties in sintered parts but among them controlling type and quantity of alloying elements and manufacturing parameters such as compacting pressure, sintering temperature are the most effective. In this research, two series of Cr-Mo prealloyed powders with 1.5% and 3% chromium contents were used, and then influences of manufacturing parameters on physical and mechanical properties were investigated. The results show that by compacting pressure and sintering temperature increment and chromium content decrement, density is increased and subsequently physical and mechanical properties of low alloyed sintered steels are improved.
- انتشار مقاله: 10-04-1393
- نویسندگان: M. Azadbeh,N. Peyghambardoust,VM. Mohammadpour,A. Kalantari
- مشاهده
- جایگاه : پژوهشی
- مجله: Archives of Razi Institute
- نوع مقاله: Journal Article
- کلمات کلیدی: cancer,Apoptosis,Newcastle disease virus,Oncolytic Virus,Breast Adenocarcinoma Cell
- چکیده:
- چکیده انگلیسی: The innovation of therapeutic modalities with better clinical efficacy is necessary for the treatment of patients with advanced cancers. Newcastle disease virus (NDV), an avian pathogenic virus, is one of the most promising oncolytic viruses that can replicate selectively in human cancer cells. In humans, NDV can cause transient conjunctivitis and mild flu-like symptoms. However, this virus poses no hazard to human health. The elucidation of the mechanisms of cancer cell killing by NDV is helpful for the clinical application of NDV in cancer patients. Regarding this, the present study was performed to evaluate apoptosis induction by NDV LaSota strain vaccine in human breast carcinoma cells. To this end, MCF-7 cells, a human breast adenocarcinoma cell line, were infected with NDV in vitro. Tumor cell cytotoxicity, apoptosis induction, and expression levels of apoptosis-related genes were examined in NDV-infected breast carcinoma cells. Tumor cell cytotoxicity was measured by 3-[4,5-dimethylthiazol-2yl]2,5-diphenyl-tetrazoliumbromide (MTT) assay. The induction of apoptosis was assessed by annexin V/propidium iodide staining. In addition, the expression levels of apoptosis-related genes were evaluated using real-time reverse transcription polymerase chain reaction (PCR) technique. The NDV showed cytotoxic effects on MCF-7 cells and induced apoptosis in the infected carcinoma cells. The gene expression levels of BAX, caspase-9, and caspase-3, but not BAK-1, were increased in NDV-infected cancer cells, compared to the gene expression levels in the non-infected cancer cells. These results suggest that the induction of the intrinsic pathway of apoptosis is one of the mechanisms that can contribute to cancer cell killing by NDV. Additional studies are required to investigate other probable mechanisms involved in NDV-mediated cancer cell killing.
- انتشار مقاله: 31-01-1398
- نویسندگان: A. Kalantari,S. Farashi Bonab,H. Keyvanfar,P. Mortazavi
- مشاهده