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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Interdisciplinary Journal of Virtual Learning in Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: E-Learning,Interactive web,Intelligent Web
- چکیده:
- چکیده انگلیسی: Web learning is a learning method in which the Web and its various services are used as a teaching tool for diverse learning activities. This can be a fully online learning process implemented through one of the web services, where the curriculum and learning activities are online or blended and intelligent. With the ever growing popularity of computers and networks, web learning (e-learning) has turned into a more feasible and accepted approach worldwide (1). Being an essential tool for supporting education and learning, the Web has become an important component of higher education programs. A variety of learning activities including communication, information retrieval, collaboration, evaluation, etc. are performed in this network. Researchers believe that web learning will continue to grow and claim a larger share of the higher education market.
- انتشار مقاله: 17-09-1398
- نویسندگان: Mohammad Bagher Negahban,A Selvaraja
- مشاهده
- جایگاه : پژوهشی
- مجله: Interdisciplinary Journal of Virtual Learning in Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: E-Learning,Interactive web,Intelligent Web
- چکیده:
- چکیده انگلیسی: Web learning is a learning method in which the Web and its various services are used as a teaching tool for diverse learning activities. This can be a fully online learning process implemented through one of the web services, where the curriculum and learning activities are online or blended and intelligent. With the ever growing popularity of computers and networks, web learning (e-learning) has turned into a more feasible and accepted approach worldwide (1). Being an essential tool for supporting education and learning, the Web has become an important component of higher education programs. A variety of learning activities including communication, information retrieval, collaboration, evaluation, etc. are performed in this network. Researchers believe that web learning will continue to grow and claim a larger share of the higher education market.
- انتشار مقاله: 17-09-1398
- نویسندگان: Mohammad Bagher Negahban,A Selvaraja
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Hodgkin lymphoma,polymorphisms,DNA Repair,PMAIP1/Noxa,TLR4
- چکیده:
- چکیده انگلیسی:
Background: Single nucleotide polymorphisms (SNPs) in DNA repair and Toll-like receptor (TLR) genes have been reported to be associated with Hodgkin Lymphoma (HL) risk. Since such associations may be ethnicity dependent, polymorphisms in TLR4 rs1554973, Xeroderma pigmentosum C (XPC) rs2228000, rs2228001 and a variant near PMAIP1/Noxa gene rs8093763 were here investigated with regard to HL susceptibility in a south Indian population. Normative frequencies of SNPs were established and compared with data for 1000 genome populations. Methods: We conducted a case control study consisting of 200 healthy volunteers and 101 cases with HL. DNA samples were genotyped using real-time PCR. Linkage disequilibrium (LD) analysis between rs2228000 and rs2228001 was performed using HaploView (version 4.2). Results: Among the studied variants, we observed that a variant rs8093763 located near PMAIP1/Noxa gene was associated with HL risk (OR=1.72 and 95% CI=1.004-2.93). The major allele frequencies of XPC (rs2228000 and rs2228001), TLR4 (rs1554973) and PMAIP1/NOXA (rs8093763) variants were 79%, 66%, 67% and 59% respectively. The studied frequencies were significantly different from 1000 genome populations. Conclusion: The results suggest that a variant rs8093763 located near the PMAIP1/Noxa gene may modify risk of HL. We found variation in distribution of polymorphic frequencies between the study population and 1000 genome populations. The results may help identify individual risk of development of HL in our south Indian population.- انتشار مقاله: 14-03-1396
- نویسندگان: Dimpal N Thakkar,Sunitha Kodidela,Sandhiya Selvarajan,Biswajit Dubashi,Steven Dkhar
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Hodgkin lymphoma,polymorphisms,DNA Repair,PMAIP1/Noxa,TLR4
- چکیده:
- چکیده انگلیسی:
Background: Single nucleotide polymorphisms (SNPs) in DNA repair and Toll-like receptor (TLR) genes have been reported to be associated with Hodgkin Lymphoma (HL) risk. Since such associations may be ethnicity dependent, polymorphisms in TLR4 rs1554973, Xeroderma pigmentosum C (XPC) rs2228000, rs2228001 and a variant near PMAIP1/Noxa gene rs8093763 were here investigated with regard to HL susceptibility in a south Indian population. Normative frequencies of SNPs were established and compared with data for 1000 genome populations. Methods: We conducted a case control study consisting of 200 healthy volunteers and 101 cases with HL. DNA samples were genotyped using real-time PCR. Linkage disequilibrium (LD) analysis between rs2228000 and rs2228001 was performed using HaploView (version 4.2). Results: Among the studied variants, we observed that a variant rs8093763 located near PMAIP1/Noxa gene was associated with HL risk (OR=1.72 and 95% CI=1.004-2.93). The major allele frequencies of XPC (rs2228000 and rs2228001), TLR4 (rs1554973) and PMAIP1/NOXA (rs8093763) variants were 79%, 66%, 67% and 59% respectively. The studied frequencies were significantly different from 1000 genome populations. Conclusion: The results suggest that a variant rs8093763 located near the PMAIP1/Noxa gene may modify risk of HL. We found variation in distribution of polymorphic frequencies between the study population and 1000 genome populations. The results may help identify individual risk of development of HL in our south Indian population.- انتشار مقاله: 14-03-1396
- نویسندگان: Dimpal N Thakkar,Sunitha Kodidela,Sandhiya Selvarajan,Biswajit Dubashi,Steven Dkhar
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Hodgkin lymphoma,polymorphisms,DNA Repair,PMAIP1/Noxa,TLR4
- چکیده:
- چکیده انگلیسی:
Background: Single nucleotide polymorphisms (SNPs) in DNA repair and Toll-like receptor (TLR) genes have been reported to be associated with Hodgkin Lymphoma (HL) risk. Since such associations may be ethnicity dependent, polymorphisms in TLR4 rs1554973, Xeroderma pigmentosum C (XPC) rs2228000, rs2228001 and a variant near PMAIP1/Noxa gene rs8093763 were here investigated with regard to HL susceptibility in a south Indian population. Normative frequencies of SNPs were established and compared with data for 1000 genome populations. Methods: We conducted a case control study consisting of 200 healthy volunteers and 101 cases with HL. DNA samples were genotyped using real-time PCR. Linkage disequilibrium (LD) analysis between rs2228000 and rs2228001 was performed using HaploView (version 4.2). Results: Among the studied variants, we observed that a variant rs8093763 located near PMAIP1/Noxa gene was associated with HL risk (OR=1.72 and 95% CI=1.004-2.93). The major allele frequencies of XPC (rs2228000 and rs2228001), TLR4 (rs1554973) and PMAIP1/NOXA (rs8093763) variants were 79%, 66%, 67% and 59% respectively. The studied frequencies were significantly different from 1000 genome populations. Conclusion: The results suggest that a variant rs8093763 located near the PMAIP1/Noxa gene may modify risk of HL. We found variation in distribution of polymorphic frequencies between the study population and 1000 genome populations. The results may help identify individual risk of development of HL in our south Indian population.- انتشار مقاله: 14-03-1396
- نویسندگان: Dimpal N Thakkar,Sunitha Kodidela,Sandhiya Selvarajan,Biswajit Dubashi,Steven Dkhar
- مشاهده