Pretreatment Neutrophil-to-Lymphocyte ratio (NLR) and Platelet-to-Lymphocyte Ratio (PLR) as a Predictive Value of Hematological Markers in Cervical Cancer

Pretreatment Neutrophil-to-Lymphocyte ratio (NLR) and Platelet-to-Lymphocyte Ratio (PLR) as a Predictive Value of Hematological Markers in Cervical Cancer

  • عنوان فارسی : Pretreatment Neutrophil-to-Lymphocyte ratio (NLR) and Platelet-to-Lymphocyte Ratio (PLR) as a Predictive Value of Hematological Markers in Cervical Cancer
  • عنوان انگلیسی : Pretreatment Neutrophil-to-Lymphocyte ratio (NLR) and Platelet-to-Lymphocyte Ratio (PLR) as a Predictive Value of Hematological Markers in Cervical Cancer
  • مجله : Asian Pacific Journal of Cancer Prevention
  • issn(مجله) : 1513-7368
  • نوع مقاله: Journal Article
  • زبان: انگلیسی
  • نوع انتشار: مقاله چاپ شده
  • انتشار مقاله: 25-06-1397
  • شماره(No): 3
  • جایگاه : پژوهشی
  • دوره: 20
  • شماره صفحه: 863,868
  • تعداد نویسندگان: 8
  • doI: 10.31557/APJCP.2019.20.3.863
  • مقاله مستخرج از:
  • نویسندگان: I Putu Yuda Prabawa , Agha Bharghah , Firdy Liwang , Deasy Ayuningtyas Tandio , Aditya Leonard Tandio , Anak Agung Wiradewi Lestari , I Nyoman Gede Budiana , Ida Bagus Amertha Putra Manuaba ,
  • چکیده:
  • چکیده انگلیسی: Background: Inflammation represents a pivotal role in the progression of cervical cancer. The hematological
    markers of inflammation in complete blood count (CBC) panel are potentially useful in determining the prognosis of
    the disease. Objective: The aim of the study was to investigate whether the pretreatment neutrophil-to-lymphocyte ratio
    (NLR) and platelet-to-lymphocyte ratio (PLR) could be used as in predicting the stage of cervical cancer. Methods:
    A retrospective cross-sectional study involving 282 patients with cervical cancer was enrolled at Sanglah General
    Hospital for five years (2013-2017). The histopathological records and complete blood counts (CBC) of the patients were
    collected and analyzed using SPSS ver. 16 software. FIGO stage I–II and III-IV were classified as early and advance
    stage respectively. Results: The median NLR and PLR were significantly higher in the advance stage compared with
    early stage (7.58 (1.36-33.20) and 247.89 (97.10-707.11); p-value = 0.001). A strong positive correlation was found
    between the staging of cervical cancer and NLR (r=0.638) and PLR (r=0.668). The AUC, sensitivity, and specificity
    value of NLR and PLR were 0.803 (82%; 71%) and 0.716 (72%; 70%). Advanced stage of cervical cancer was found
    in high NLR (adjusted OR: 9.02; 95%CI=2.42-33.64; p=0.001) and PLR (adjusted OR = 2.47; 95% CI = 1.45-4.85;
    p = 0.032). Conclusion: Increased pretreatment NLR and PLR values may provide a useful information in predicting
    the staging of cervical cancer.
Pretreatment Neutrophil-to-Lymphocyte ratio (NLR) and Platelet-to-Lymphocyte Ratio (PLR) as a Predictive Value of Hematological Markers in Cervical Cancer

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