چکیده انگلیسی:
Background:Indonesia is one of the countries in the world with the most coal production as fuel. Coal fly ash (CFA) is the result of coal combustion process, consisting of various minerals and contributing to health risks due to toxic effects by inhalation. This study aimed to analyze the toxic effects of CFA inhalation in mice models by examining oxidative stress and inflammation markers in the blood. Methods:Twenty-four mice were randomly divided into three groups including control (P1), CFA inhalation for 24 hours (P2), and CFA inhalation for 30 days (P3). Mice in the P2 and P3 groups were exposed to CFA measuring 0.075 mm with doses equal to 12.5 mg/m3 for 1 hour/day. Malondialdehyde (MDA) and the percentage of blood eosinophils were examined as parameters of the toxic effects of CFA inhalation. One way analysis of variance (ANOVA) test was used to compare the toxic effects between groups. Results:MDA were significantly increased in between groups (p <0.05). The percentage of blood eosinophils in P1 was significantly differenced to P2 and P3 (p=0.04 and p=0.14, respectively), however there was no difference between P2 and P3 (p = 0.891). Conclusions:CFA inhalation induces toxic effects through increased oxidative stress and inflammation in mice models. It may indicates health hazards after CFA inhalation.
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